I think I've not been as enthralled by a show since Six Feet Under. This is quality TV : great acting, great writing, great premisse and great execution. I can't recommend it enough. They get bonus points for having a character with mild cerebral palsy actually played by a teen with mild cerebral palsy (it really shouldn't be so exceptional).
I also want to say that Bryan Cranston is a GOD. I almost didn't recognize him (he's Malcolm's father in Malcolm in the middle). He has already made me cry several times and I'm not even at the end of season one yet (ok, I cry easily, but hush).